If you are looking for work, persistence is a good thing to keep in mind. With so many people applying for the same jobs it is also important to keep a positive attitude and to try and explore all of the options available.
One of the most under utilized job searching tools is friends and family. Use social media like facebook and twitter to let everyone know you are looking for employment. Even a very casual acquaintance might be your ticket to land a great gig in this challenging time. Charlotte, NC Craigslist is a site I would say is also a great place to start looking for that new dream career - and it is out there, even with all of the bad news.